Cyclobenzaprine vs. Soma (carisoprodol)

Cyclobenzaprine vs. Soma (carisoprodol)

Cyclobenzaprine vs. Soma: What’s the difference?

What is cyclobenzaprine? What is Soma?

Cyclobenzaprine is a muscle relaxant used with rest and physical therapy for short-term relief of muscle spasms associated with acute painful muscle and skeletal conditions. It is only for short-term use, up to two or three weeks. Cyclobenzaprine relieves muscle spasm when the spasm is due to local problems, that is, in the muscle itself and not in the nerves controlling the muscles. Cyclobenzaprine seems to accomplish its beneficial effect through a complex mechanism within the nervous system, probably in the brainstem.

Soma (carisoprodol) is an oral muscle relaxant used together with rest and physical therapy for the short-term relief of acute painful muscle and skeletal conditions in adults. It is only used for 2 to 3 weeks. Its exact mechanism of action is unknown. It may work by altering communication among nerves in parts of the brain that control the sensation of pain and in the spinal cord.

What are the side effects of cyclobenzaprine and Soma?

Cyclobenzaprine

The most common side effects of cyclobenzaprine include:

Other reported side effects include:

Possible serious side effects include:

Abrupt cessation after prolonged therapy may cause withdrawal symptoms such as headaches, nausea, and weakness.

Soma

The most common side effects of carisoprodol are:

Serious side effects of carisoprodol include:

Carisoprodol is not a controlled substance. Patients may become dependent on carisoprodol, and discontinuation after long-term use may cause withdrawal symptoms.

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What is the dosage of cyclobenzaprine vs. Soma?

Cyclobenzaprine

  • The recommended dose of cyclobenzaprine dose is 5 or 10 mg three times daily using immediate release tablets or 15 or 30 mg once daily using extended release tablets.

Soma

  • The recommended dose of carisoprodol is 250 or 350 mg three times daily and at bedtime.
  • The recommended treatment duration is 2 to 3 weeks.
  • To avoid withdrawal symptoms, carisoprodol should be stopped gradually if it has been used for a long duration.

What drugs interact with cyclobenzaprine and Soma?

Cyclobenzaprine

  • Cyclobenzaprine is chemically related to the tricyclic class of antidepressants, for example, amitriptyline (Elavil, Endep), nortriptyline Pamelor). As such, it should not be taken with or within two weeks of any monoamine oxidase (MAO) inhibitor, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane). High fever, convulsions, and even death can occur when these drugs are used together.
  • Cyclobenzaprine interacts with other medications and drugs that slow the brain’s processes, such as

Soma

  • Carisoprodol interacts with other medications and drugs that slow the brain’s processes, such as alcohol, barbiturates, benzodiazepines (for example, lorazepam [Ativan]), and narcotics, accentuating their effects and causing drowsiness.
  • Omeprazole (Prilosec) and fluvoxamine (Luvox) may reduce the elimination of carisoprodol, leading to increased side effects.
  • St. John’s Wort and rifampin (Rifadin) increase the elimination of carisoprodol, possibly resulting in a reduced effect.

Are cyclobenzaprine and Soma safe to use while pregnant or breastfeeding?

Cyclobenzaprine

  • There are no adequate studies of cyclobenzaprine in pregnant women. However, studies in animals suggest no important effects on the fetus. Cyclobenzaprine therefore can be used in pregnancy if the physician feels that it is necessary.
  • It is not known whether cyclobenzaprine is secreted in milk. However, since it is related to the tricyclic antidepressants, some of which are excreted in breast milk, caution is advised in using this medication in women who are breastfeeding.

Soma

  • There are no adequate studies of carisoprodol in pregnant women.
  • Carisoprodol accumulates in breast milk in concentrations twice those of the mother’s blood. The effects of carisoprodol on the infants of lactating mothers are unknown. Therefore, caution should be used when using carisoprodol in women who are breastfeeding.

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Medically Reviewed on 6/5/2019

References

REFERENCE:

FDA Prescribing Information

Source: Medicinenet.com (Feeds API) – Daily Exercise